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Hydrolysis of arzoxifene sulfate by human placental STS. Arzoxifene possesses a single benzothiophene hydroxyl group capable of being sulfated. The figure shows the monosulfates formed by SULT2A1 with raloxifene (Ral) and arzoxifene (Arz), respectively, with and without subsequent incubation with placental STS (+ STS).
