Skip to main content
. Author manuscript; available in PMC: 2009 Jun 16.
Published in final edited form as: Dev Biol. 2007 Nov 28;314(1):137–149. doi: 10.1016/j.ydbio.2007.11.022

Figure 3.

Figure 3

CG5336 encodes ELMO/Dced-12. (A) Drosophila ELMO is the ortholog of C. elegans CED-12 and human ELMO1. The N-termini of these proteins share predicted Armadillo repeats, while the C-terminal region contains a pleckstrin homology (PH) domain and proline-rich region. (B) The intron/exon organization of the CG5336/elmo locus is shown. The PiggyBac transposable element PB[c06760] is located in the first intron. (C) The molecular lesions obtained in an EMS screen for elmo mutants are indicated. (D) The molecular lesion in the EMS-induced allele elmo8C6 occurs in a conserved glycine at amino acid position 666 within the PH domain.