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. Author manuscript; available in PMC: 2009 Jun 17.

Published in final edited form as: J Mol Biol. 2009 Mar 13;386(5):1278–1289. doi: 10.1016/j.jmb.2009.01.028

Table 2.

Thrombin and factor Xa inhibition by the AT variants.

		Thrombin			fXa

AT	H5	SI	k_app (mM⁻¹s⁻¹)	k_app x SI	SI	k_app (mM⁻¹s⁻)	k_app x SI

S137A	−	1.04± 0.01	8.23 ± 0.21	8.56 ± 0.17	1.04± 0.05	5.59± 0.10	5.81± 0.21
	+				1.19±0.01	756± 9	900±9
V375C	−	1.08± 0.01	7.06 ± 0.32	7.62 ± 0.25	1.13± 0.02	7.12± 0.15	8.05± 0.16
	+				1.24±0.04	664± 15	823±23
S380C	−	1.66± 0.06	5.47 ± 0.09	9.08 ± 0.25	1.63± 0.01	0.961± 0.025	1.57± 0.30
	+				2.03± 0.05	194± 1	394±6
V375C/S380C	−	2.11± 0.06	3.08 ± 0.05	6.50 ± 0.15	1.99± 0.01	0.430± 0.015	0.856± 0.021
	+				2.08± 0.03	0.331± 0.036	0.688±0.053