Table 1.

Anti-proliferation and ATPase activity of cis-amide analogues. IC₅₀ values are expressed in μM concentrations unless noted otherwise.

compound	MCF7	SKBR3	ATPase
15	3.2 ± 0.1	1.8 ± 0.1	2.4 ± 0.1
16	78.9 ± 11.3	57.1 ± 8.4	–
17	1.5 ± 0.1	1.2 ± 0.1	1.6 ± 0.0
18	9.8 ± 1.9	15.9 ± 4.1	–
19	4.8 ± 1.1	7.3 ± 0.2	–
20	6.3 ± 0.9	7.8 ± 0.2	–
21	3.6 ± 0.1	2.1 ± 0.2	1.5 ± 0.1
22	14.9 ± 0.2	15.4 ± 0.8	–
23	2.7 ± 0.5	2.1 ± 0.7	1.2 ± 0.0
24	78.0 ± 4.4	15.4 ± 0.8	–
Radamide	18.6 ± 0.9a	23.7 ± 1.7a	5.9b
GDA	9.8 ± 0.1 nM	8.5 ± 1.1 nM	2.5 ± 0.4
RDC	47.7 ± 2.6 nM	37.5 ± 4.0 nM	0.4 ± 0.0

IC₅₀ = concentration needed to produce 50% inhibition,

^a= results obtained from recently submitted manuscript,

^b= obtained from reference #²¹.