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Simulation of the action potential. (A) Using a modified FMG model as described in Methods, inactivation kinetics were accelerated by 23% in the simulated APC ICa,L compared with the Control ICa,L. (B) Simulated changes in the AP (control vs. APC) are shown as the corresponding consequence of the accelerated ICa,L inactivation. The APD50 and APD90 were 83.0 and 98.1 ms, respectively, in the control-simulated AP, and 77.8 and 92.9 ms in the APC-simulated AP.
