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Effect of Ca2+ sensitivity on ICa,L inactivation. The effect of altering the sensitivity of L-type Ca channels to intracellular Ca2+ on ICa,L inactivation was simulated using the modified FMG model. Ca2+ sensitivity was enhanced by 28% (dashed lines) relative to the control. The exponential fits are depicted by the dotted lines. This enhancement of Ca2+ sensitivity induced only 5% change in the acceleration of the ICa,L inactivation.
