Table 2.

Pharmacokinetic parameters for atorvastatin (AT) and hydroxyatorvastatin (AT-OH) following atorvastatin monotherapy or in combination with MB07811 on day 8 in monkeys

Group	Analyte	AUClast (µg·h·mL−1)	Cmax (µg·mL−1)	MRT (h)	t1/2 (h)
AT	AT	0.06 ± 0.02	0.009 ± 0.005	4.47 ± 2.51	8.00 ± 1.47
MB07811 + AT	AT	0.07 ± 0.04	0.013 ± 0.009	6.98 ± 1.41	7.56 ± 2.92
AT	AT-OH	0.10 ± 0.07	0.007 ± 0.004	10.23 ± 1.37	14.14 ± 3.57
MB07811 + AT	AT-OH	0.09 ± 0.06	0.008 ± 0.004	8.71 ± 1.72	10.62 ± 4.35

Data shown in Table are means ± SD from 12 animals per group.

AUC_last, area under the curve; C_max, maximum observed concentration; MRT, mean residence time; t_1/2, terminal half-life.