Table 3.
Effects of pre-incubation with DAT inhibitors of DAMGO-mediated calcium mobilization
| DAMGO |
RTI-371 |
JHW007 |
JHW007 |
|
|---|---|---|---|---|
| 10 µmol·L−1 | 1 µmol·L−1 | 10 µmol·L−1 | ||
| Emax (%) | 97 | 99 | 97 | 68* |
| 2 | 2 | 2 | 2 | |
| EC50 (nmol·L−1) | 5.7 | 6 | 5.7 | 9.5 |
| 4.5–7.3 | 4.7–7.5 | 4.2–7.9 | 5.5–16 | |
| Hill slope | 1.1 | 1.1 | 0.9 | 0.8 |
| 0.1 | 0.1 | 0.1 | 0.2 |
This Table contains the Emax, EC50 and Hill slope data for the data presented in Figure 3. The 95% confidence interval is given for the EC50 data because the error is not symmetrically distributed around the mean. The asterisk indicates significant difference from the corresponding DAMGO value.