Figure 6.

Effects of 10 µmol·L⁻¹ CPA, 1 mmol·L⁻¹ caffeine, 60 µmol·L⁻¹ 2-APB, 1 mmol·L⁻¹ neomycin, 1 µmol·L⁻¹ ryanodine on the phenylephrine-evoked contractions of isolated strips of the guinea pig prostate. The strips were exposed to these modulating agents, in the presence of Ca²⁺-free Krebs solution for 30 min. The AUC of the phenylephrine contractions (100 µmol·L⁻¹ for 2 min) was then recorded and expressed as a percent of the AUC of the control contractions, recorded in the absence of these agents. The AUC values of phenylephrine-evoked contractions were reduced significantly (P < 0.05; n= 6–7) by 10 µmol·L⁻¹ CPA, 1 mmol·L⁻¹ caffeine, 60 µmol·L⁻¹ 2-APB, 1 mmol·L⁻¹ neomycin or 1 µmol·L⁻¹ ryanodine. 2-APB, 2-aminoethoxy-diphenylborate; AUC, area under the curve; CPA, cyclopiazonic acid.