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. 2009 Feb 2;156(4):545–562. doi: 10.1111/j.1476-5381.2009.00052.x

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© 2009 The Authors. Journal compilation © 2009 The British Pharmacological Society

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NS-309 induces endothelium-dependent hyperpolarization. (A) Chemical structure of NS-309, an activator of calcium-activated potassium channels of intermediate and small conductance. (B) Original membrane potential recordings showing the effects of acetylcholine (ACh) and NS-309 in vascular smooth muscle of the guinea pig carotid artery with endothelium (in the presence of inhibitors of nitric oxide synthase and cyclooxygenase). (C) Concentration-dependent effects of NS-309. (D) Summary of the effects of endothelial removal on ACh-, NS-309- and levcromakalim (Levcrom.)-induced hyperpolarization. (E) Effects of the combinations of apamin plus charybdotoxin on ACh-, NS-309- and levcromakalim-induced hyperpolarizations. Modified from Leuranguer et al. (Naunyn Schmiedebergs Arch Pharmacol, 2008).