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. 2009 Mar 4;156(6):869–884. doi: 10.1111/j.1476-5381.2008.00078.x

Table 1.

Orthosteric binding site homology of family C receptor subtypesa

mGlu1 Y74 R78 W110 G163 S164 S165 S166 S186 A187 T188 S189 D208 Q211 Y236 E292 G293 D318 G319 W320 R323 K409
mGlu5 Y64 R68 W100 G149 S150 S151 S152 S172 A173 T174 S175 D194 Q197 Y222 E278 G279 D304 G305 W306 R309 K395
mGlu2 R57 R61 S93 S143 Y144 S145 D146 A166 S167 T168 S169 D188 Q191 Y226 R271 S272 D295 G296 W297 L300 K377
mGlu3 R64 R68 S100 S149 Y150 S151 S152 A172 S173 T174 S175 D194 Q197 Y222 R277 S278 D301 G303 W303 Q306 K389
mGlu4 K74 R78 S110 S157 G158 S159 S160 A180 S181 T182 A183 D202 Q205 Y230 N286 E287 D312 S313 W314 K317 K405
mGlu6 Q58 R62 S94 S146 A147 S148 S149 A169 S170 T171 A172 D191 Q194 Y219 N275 E276 D301 S302 W303 K306 K394
mGlu7 N74 R78 S110 S157 G158 S159 S160 A180 S181 T182 A183 D202 Q205 Y230 N288 D289 D314 S315 W316 K319 K407
mGlu8 K71 R75 S107 A154 A155 S156 S160 A177 S178 T179 A180 D199 Q202 Y227 N283 E284 D309 S310 W311 K314 K401
CaR R66 W70 N102 T145 G146 S147 G148 A168 S169 S170 S171 D190 Q193 Y218 S272 G273 E297 A298 W299 S302 I416
GPRC6A S69 Q73 T104 G147 Y148 S149 E150 E170 S171 T172 A173 D192 Q195 Y220 R279 Q280 D303 N304 W305 A308 L411
T1R1 H71 L75 S107 D147 S148 T149 N150 A170 A171 S172 S173 D192 Q195 Y220 S276 R277 E301 A302 W303 S306 S385
GABAB1a G183 C187 C220 G244 C245 S246 S247 G267 S268 S269 S270 A289 H292 V317 F365 E367 G393 W394 Y395 – G461
a

List of residues within 6 Å of l-Glu bound to mGlu1 (Madsen et al., 2005) based on previously published protein sequence alignments (Bräuner-Osborne et al., 1999; Galvez et al., 1999; Wellendorph and Bräuner-Osborne, 2004). Residues in bold are known to interact with l-Glu either directly or indirectly via water molecules in mGlu1 and mGlu3 respectively (Kunishima et al., 2000; Muto et al., 2007). Underlined and italic residues interact with the α-amino acid or distal carboxylic acid moiety of l-Glu respectively (Kunishima et al., 2000; Muto et al., 2007). Highly conserved residues involved in binding of the α-amino acid moiety or the distal carboxylic acid moiety of l-Glu are shown in red and green respectively.

CaR, calcium-sensing receptor; GABAB, γ-aminobutyric acid type B; GPRC6A, G-protein-coupled receptor family C, group 6, subtype A; mGlu, metabotropic glutamate; T1R, taste1 receptor.