Table 1.

V_max, K_m, and CL_int for the disappearance of oltipraz in hepatic and intestinal microsomes from LC, DM, LCD and control rats

Parameter	Control	LC	DM	LCD
Hepatic
Vmax (nmol·min−1 mg·protein−1)	5.38 ± 0.382*	1.84 ± 0.480*	9.49 ± 1.22*	2.91 ± 0.497*
Km (µmol·L−1)	29.3 ± 5.59	46.4 ± 34.5	38.2 ± 5.88	24.8 ± 6.12
CLint (mL·min−1 mg·protein−1)	0.184 ± 0.0129*	0.0530 ± 0.0228*	0.250 ± 0.0125*	0.119 ± 0.0111*
Total protein (mg whole liver−1)	373 ± 113	121 ± 24.7#	239 ± 13.6	143 ± 35.7#
Intestinal
Vmax (nmol·min−1 mg·protein−1)	0.523 ± 0.231	0.268 ± 0.169	0.257 ± 0.137	0.212 ± 0.182†
Km (µmol·L−1)	6.41 ± 2.60	4.60 ± 2.24	2.54 ± 1.76†	4.28 ± 2.38
CLint (mL·min−1 mg·protein−1)	0.0807 ± 0.00444	0.0556 ± 0.00950#	0.109 ± 0.0307	0.0451 ± 0.0122#
Total protein (mg whole intestine−1)	6.93 ± 1.23	5.37 ± 2.99	7.13 ± 2.90	4.83 ± 3.29

Data are expressed as mean ± SD (n= 4–6, each).

^*Each group was significantly different (P < 0.05).

^#Control and DM groups were significantly different from LCD and LC groups (P < 0.05).

^†Significantly different (P < 0.05) from control.