Table 2.
Pharmacokinetic parameters of oltipraz after i.v. administration at a dose of 10 mg·kg−1 to LC, DM, LCD and control rats
| Parameter | Control | LC | DM | LCD |
|---|---|---|---|---|
| Initial body weight (g) | 188 ± 10.3 | 198 ± 9.94 | 199 ± 12.5 | 194 ± 8.50 |
| Final body weight (g) | 376 ± 24.7† | 299 ± 9.45* | 282 ± 13.2* | 250 ± 26.9# |
| Blood glucose (mmol·L−1) | 5.90 ± 0.314† | 5.80 ± 0.751† | 20.7 ± 4.44* | 19.1 ± 4.62* |
| AUC (µg·min−1·mL−1) | 249 ± 32.9† | 531 ± 103* | 157 ± 34.2† | 350 ± 132# |
| CL (mL·min−1·kg−1) | 40.8 ± 6.03† | 19.3 ± 3.06* | 65.3 ± 15.5 | 34.1 ± 18.6† |
| Terminal t1/2 (min) | 80.5 ± 11.9† | 116 ± 20.0* | (33.2 ± 5.65)a | 68.9 ± 27.4† |
| MRT (min) | 84.1 ± 17.1† | 132 ± 25.8* | (39.9 ± 9.04) | 90.0 ± 37.2† |
| Vss (mL·kg−1) | 3350 ± 351† | 2500 ± 391* | (2570 ± 278) | 2700 ± 901 |
| Ae0–24 h (% of dose) | BD | BD | BD | BD |
| GI24 h (% of dose) | BD | BD | BD | BD |
Data are expressed as mean ± SD (control and DM, n= 8; LC, n= 7; LCD, n= 11).
a
The numbers in parentheses were not included in statistical analysis, because the detection of plasma concentrations of oltipraz in DM rats was shorter than other rats.
Values of each parameter with different marks (†, *, #) are significantly different; P < 0.05.
BD, below the detection limit.