Table 3.
Pharmacokinetic parameters of oltipraz after p.o. administration at a dose of 30 mg·kg−1 to LC, DM, LCD and control rats
| Parameter | Control | LC | DM | LCD |
|---|---|---|---|---|
| Initial body weight (g) | 214 ± 16.9 | 223 ± 9.64 | 201 ± 7.66 | 216 ± 13.6 |
| Final body weight (g) | 334 ± 10.3† | 246 ± 16.2* | 285 ± 13.2# | 221 ± 22.0§ |
| Blood glucose (mmol·L−1) | 5.42 ± 0.531† | 5.61 ± 0.583† | 16.3 ± 2.59* | 16.9 ± 3.50* |
| AUC (µg·min−1·mL−1) | 286 ± 78.7† | 812 ± 188* | 134 ± 29.1# | 438 ± 164§ |
| Terminal t1/2 (min) | 168 ± 46.6† | 423 ± 111* | 157 ± 58.8† | 126 ± 29.8† |
| Cmax (µg·mL−1) | 0.689 ± 0.166† | 1.06 ± 0.227* | 0.440 ± 0.148# | 1.16 ± 0.322* |
| Tmax (min) | 368 ± 113 | 308 ± 74.8 | 267 ± 124 | 370 ± 134 |
| GI24 h (% of dose) | 3.68 ± 3.85 | 4.26 ± 6.17 | 3.12 ± 4.46 | 5.63 ± 4.63 |
| F (%) | 38.3 | 51.0 | 28.5 | 41.7 |
Data are expressed as mean ± SD (control and LC, n= 8; DM, n= 9; LCD, n= 6). Values of each parameter with different marks (†, *, #, §) are significantly different; P < 0.05.