Figure 4.
Effects of acute application of fluvastatin (A) on resting chloride channel conductance (gCl) measured in untreated rat extensor digitorum longus muscle. The dose-response relationship was constructed by calculating the residual gCl at different concentrations of fluvastatin. Each data point was calculated as the mean ± SEM of gCl from 27 to 60 fibres of 5–7 rats. *Significantly different with respect to control (P < 0.05 or less) by Student's t-test. In (B) is shown the effect of chelerythrine (1 µmol·L−1) application in muscle bath containing 50 µmol·L−1 of fluvastatin. The protein kinase C inhibitor completely prevented the reduction of gCl induced by the statin by shifting gCl towards the control (CTRL) value.