Figure 1.

Experimental protocols. Four separate experiments were performed, and the feeding schedules and diets (double-head arrows) used are indicated for each experiment. Blood samples were taken at multiple time points (arrowheads) and used for serum parameter determinations. For biological and pathological analyses, animals in each group were sacrificed and tissue samples were taken at various time points (round-bottomed arrows). aVD₃, active vitamin D₃; Cal, CaCO₃; MC, methylcellulose; Sev, sevelamer.