Table 1.

Effects on serum phosphate levels and survival in rats orally dosed with different amounts of adenine

Days	Serum phosphate, mg·mL−1 (survival rate, %)
	Adenine (mg·kg−1)					Normal
	500	600	700	800	900
−6	0.0766 ± 0.0010	0.0753 ± 0.0065	0.0823 ± 0.0064	0.0974 ± 0.0170	0.1300 ± 0.0146	0.0783 ± 0.0015
	(100)	(100)	(100)	(75)	(50)	(100)
−2	0.1119 ± 0.0082	0.1393 ± 0.0212	0.1506 ± 0.0289	0.1353 ± 0.0310	–	0.0853 ± 0.0050
	(100)	(100)	(75)	(50)	(0)	(100)
0	0.1422 ± 0.0056	0.1502 ± 0.0204	0.1448 ± 0.0021	–	–	0.0727 ± 0.0059
	(100)	(100)	(50)	(0)	(0)	(100)
16	0.1008 ± 0.0073	0.1154 ± 0.0169	0.1173 ± 0.0091	–	–	0.0683 ± 0.0017
	(100)	(100)	(50)	(0)	(0)	(100)

Adenine sulphate (suspended in a 0.5% MC solution, 100 mg·mL⁻¹) ranging from 500 mg·kg⁻¹ to 900 mg·kg⁻¹ or a 0.5% MC solution (5 mL·kg⁻¹) was given orally to rats for 10 days (d −10 to d −1) (n= 4 each). Animals were fed with a normal diet during the experimental period of d −10 to d 16. Serum phosphate levels are expressed as the mean ± SD.

MC, methylcellulose.