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. 2009 Feb 18;156(5):740–750. doi: 10.1111/j.1476-5381.2008.00072.x

Figure 3.

Figure 3

N-acyl dopamine compounds inhibit recombinant human T-type calcium channels. Whole-cell patch clamp recordings were made from human CaV3.1, CaV3.2 and CaV3.3 channels stably expressed in HEK 293 cells. Currents were evoked by stepping from −86 mV to −26 mV. (A) The effect of N-arachidonoyl dopamine (NADA) N-oleoyl dopamine (OLDA) and N-palmitoyl dopamine (PALDA) on each of CaV3.1, CaV3.2 and CaV3.3. are illustrated, with a time plot for the effects of NADA. (B) A summary of the effects of 10 µmol·L−1 of each of the N-acyl dopamines on each of the recombinant human CaV3 channels. The bars are the mean ± SEM of 6–9 cells for each drug on each channel. The dotted line represents zero current.