Figure 6.

Effect of intravenous administration of four muscarinic receptor antagonists on bladder contraction, blood pressure and heart rate in guinea pigs. Amplitude of bladder contraction, mean arterial blood pressure and heart rate were measured at the same times (see Methods). The per cent change in each variable was calculated relative to baseline values. *P < 0.05, **P < 0.01 and ***P < 0.001 versus control; Student's t-test: n = 4–6 animals per compound.