Table 2.
Ex vivo affinities, shown as pA2-equivalent dose (pA2-ED) of muscarinic receptor antagonists on carbachol-induced responses in isolated bladder and atrial tissues
| Compound |
pA2-ED (mg·kg−1oral) |
Selectivity ratio | |
|---|---|---|---|
| Bladder | Atria | ||
| Tolterodine | 0.7 | 0.14 | 0.21 |
| (0.4–1.0) | (0.07–0.3) | ||
| Darifenacin | 1.6 | 3.9 | 2.4 |
| (0.35–6.7) | (2.1–7.5) | ||
| Solifenacin | 1.3 | 2.0 | 1.5 |
| (0.46–4.2) | (1.6–2.6) | ||
| SVT-40776 | 0.7 | 40.3 | 58 |
| (0.4–1.1) | (32.6–51.6) | ||
Mice were killed 3 h after receiving a single oral dose of antagonists or vehicle. Values are expressed as mean (95% CI) n = 4–6 animals for each antagonist dose, three to five doses for each compound.