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In viv o effects of treatment with M3 receptor antagonists on bladder intravesical pressure and arterial blood pressure
| Compound |
ED25 (nmol·kg−1, i.v.) |
|
|---|---|---|
| IVP inhibition | MAP increase | |
| Tolterodine | 299.2 | 820 |
| Darifenacin | 53.2 | >1000 |
| Solifenacin | 200.9 | >3000 |
| SVT-40776 | 17.1 | >3000 |
Values are calculated from n = 4–6 animals per dose. Darifenacin was not given at higher doses because of its solubility problems.
IVP, intravesical pressure; MAP, mean arterial pressure.
