Figure 3.
Effects of pre-treatment with of saline (Sal) or WAY100635 (WAY, 0.1 mg kg−1) followed by second injection of vehicle (Veh, Tween 80 2%-saline) or cannabidiol (CBD, 10 mg kg−1) immediately before a 60 min restraint period on increase in the mean arterial pressure (ΔMAP) and heart rate (ΔHR) induced by restraint stress. The arrow indicates the beginning of the restraint period. Data shown represent the mean ± SEM of five to six animals. *P < 0.05, compared with vehicle group; anova followed by Bonferroni's post hoc test.