Figure 5.
Effects in the elevated plus-maze (EPM) of a first systemic injection of saline (Sal) or WAY100635 (WAY, 0.1 mg kg−1) followed by a second injection of vehicle (Veh, Tween 80 2%-saline) or cannabidiol (CBD, 10 mg kg−1) immediately before a 60 min restraint period (n = 6 per group). A non-stressed group (no-restraint) that received i.p. injections of saline followed by vehicle was used as general control. The EPM test was performed 24 h after the restraint period. Data represent the mean (±SEM) per cent of open arm entries. *P < 0.05, compared with control group; #P < 0.05, compared with restraint-vehicle group; $P < 0.05, compared with restraint-CBD group; anova followed by Bonferroni's post hoc test.