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. 2009 Jan;156(1):62–83. doi: 10.1111/j.1476-5381.2008.00015.x

Figure 3.

Figure 3

The influence of PDE inhibitors on the positive inotropic effects of (−)-noradrenaline through β1-adrenoceptors and (−)-adrenaline through β2-adrenoceptors on left atrium. (A) Potentiation of the effects of (−)-noradrenaline by rolipram (Rol), concurrent rolipram + cilostamide and IBMX (10 µmol·L−1) but not by cilostamide (Cil) alone. (B) Effects of (−)-adrenaline mediated through β1-adrenoceptors in the presence of ICI118551 (ICI) and antagonism by CGP20712A (CGP). (C) Unmasking of functional β2-adrenoceptors by concurrent cilostamide + rolipram or IBMX (30 µmol·L−1) and antagonism by ICI118551. Fits of some biphasic curves were constrained by using the effect of (−)-isoprenaline as maximum. For further details see legend to Figure 1. Error bars are omitted in the range of curve overlap.