Table 2.

Nuclear receptor ligands currently tested in clinical trials for cholestasis

Drug	Nuclear receptor target	Cholestatic disorder	ClinicalTrials. gov weblink
INT-747 (6-ECDCA)	FXR	PBC/monotherapy	http://clinicaltrials.gov/ct2/show/NCT00570765
INT-747 (6-ECDCA)	FXR	PBC/combination therapy with UDCA	http://clinicaltrials.gov/ct2/show/NCT00550862
Fenofibrate	PPARα	PBC	http://clinicaltrials.gov/ct2/show/NCT00575042

6-ECDCA, 6-ethyl chenodeoxycholic acid; FXR, farnesoid X receptor; PBC, primary biliary cirrhosis; PPAR, peroxisome proliferator-activated receptor.