Table 3.
Summary of the data derived from the Choice Reaction Time Task after treatment with HID (L-histidine depletion), treatment with TYD (L-tyrosine/L-phenylalanine depletion) or treatment with BAL (the full amino acid mixture)
| Choice reaction time | Main effect treatment | SQ×treatment | RC×treatment |
Treatment |
|||||
|---|---|---|---|---|---|---|---|---|---|
| BAL Mean (±SEM) | HID Mean (±SEM) | TYD Mean (±SEM) | |||||||
| P | P | P | Intact | Degraded | Intact | Degraded | Intact | Degraded | |
| Reaction time (ms) | 0.786 | 0.953 | 0.395 | ||||||
| Simple | 414 (9.4) | 458 (13.2) | 414 (9.8) | 461 (12.9) | 414 (9.0) | 460 (13.5) | |||
| Complex | 443 (12.9) | 488 (15.1) | 448 (14.2) | 489 (13.6) | 439 (13.5) | 483 (16.7) | |||
| Accuracy (log%) | 0.242 | 0.649 | 0.222 | ||||||
| Simple | −0.05 (0.025) | −0.07 (0.026) | −0.01 (0.002) | −0.04 (0.009) | −0.01 (0.002) | −0.03 (0.006) | |||
| Complex | −0.02 (0.005) | −0.04 (0.008) | −0.02 (0.004) | −0.04 (0.008) | −0.01 (0.002) | −0.06 (0.006) | |||
| S-locked P300 | |||||||||
| Latency (ms) | 0.213 | 0.427 | 0.199 | ||||||
| Simple | 382 (0.4) | 394 (0.6) | 391 (0.5) | 400 (0.6) | 391 (0.3) | 402 (0.6) | |||
| Complex | 372 (0.4) | 389 (0.6) | 379 (0.5) | 389 (0.7) | 381 (0.4) | 398 (0.5) | |||
| Amplitude (µV) | 0.504 | 0.643 | 0.063 | ||||||
| Simple | 6.7 (0.07) | 5.8 (0.07) | 6.8 (0.05) | 6.3 (0.04) | 6.2 (0.06) | 6.0 (0.06) | |||
| Complex | 4.4 (0.08) | 5.2 (0.07) | 4.1 (0.06)* | 3.7 (0.05)* | 4.4 (0.06) | 3.9 (0.05) | |||
| R-locked P300 | |||||||||
| Latency (ms) | 0.181 | 0.610 | 0.641 | ||||||
| Simple | −19 (0.7) | −29 (0.6) | −15 (0.8) | −34 (0.9) | −10 (0.7) | −20 (0.7) | |||
| Complex | −59 (−1.9) | −61 (1.4) | −42 (1.1) | −73 (3.5) | −34 (1.3) | −43 (2.4) | |||
| Amplitude (µV) | 0.965 | 0.025 | 0.862 | ||||||
| Simple | 5.0 (0.06) | 4.5 (0.07) | 5.2 (0.04) | 3.9 (0.05) | 4.6 (0.05) | 4.8 (0.06) | |||
| Complex | 2.6 (0.06) | 2.1 (0.06) | 2.6 (0.06) | 2.1 (0.05) | 2.7 (0.06) | 2.2 (0.06) | |||
| S-locked LRP | |||||||||
| Onset (ms) | 0.336 | 0.218 | 0.286 | ||||||
| Simple | 252 (0.5) | 269 (0.8) | 253 (1.0) | 344 (3.5) | 270 (0.5) | 305 (2.0) | |||
| Complex | 247 (0.7) | 303 (0.7) | 279 (0.7) | 309 (1.2) | 271 (0.5) | 272 (0.5) | |||
| R-locked LRP | |||||||||
| Onset (ms) | 0.103 | 0.880 | 0.068 | ||||||
| Simple | −152 (0.9) | −152 (1.5) | −131 (0.7) | −118 (0.8) | −122 (0.7) | −124 (0.5) | |||
| Complex | −167 (1.2) | −172 (1.0) | −176 (1.2)* | −183 (1.6)* | −146 (0.5) | −152 (0.8) | |||
Significant or near significant main effects or interaction are indicated with bold P value. Significant (P < 0.05) differences in effects of response complexity (RC) after HID or TYD as compared with BAL are indicated with
*
SEMs of the electrophysiological measures are uncorrected for applying the Jackknife method.