Table 3.
Pharmacokinetic properties of A-940894
Species | Route of administration and dose (mg·kg−1) | t1/2(h) | Cmax(µmol·L−1) | Vβ(L·kg−1) | F (%) |
---|---|---|---|---|---|
Mouse | i.v. (5) | 4.9 | 0.71 | 88.9 | – |
p.o. (10) | 6.8 | 0.13 | – | 33 | |
s.c. (10) | 3.3 | 2.52 | – | – | |
Rat | i.v. (10) | 2.2 | 4.16 | 20 | – |
p.o. (10) | 3.4 | 0.51 | – | 37 | |
i.p. (10) | 3.1 | 1.63 | – | 78 |