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Representative examples of hypnograms showing the sleep–wake cycle in (A) wild-type (Ox+/+) and (B) Ox−/− mice over a 5 h period in the lights-on phase. Arrows show where vehicle (placebo) and GSK189254 (3 and 10 mg·kg−1) were administered. GSK189254 increased wakefulness (W) and decreased slow wave sleep (SWS) and paradoxical sleep (PS) in both Ox+/+ and Ox−/− mice compared with vehicle-treated mice.
