Figure 6.

Effects of acute and repeat administration of GSK189254 and effect of acute administration of modafinil on narcoleptic attacks in Ox−/− mice in the lights-off period compared with vehicle-treated mice. (A) Mean (±SEM) number of narcoleptic episodes in the 4 h period after dosing. (B) Mean (±SEM) cumulative duration of narcoleptic attacks and (C) mean (±SEM) cumulative number of narcoleptic attacks over the 12 h lights-off period. *P < 0.05, t-test between groups (compared with vehicle-treated mice) after significant anova. #P < 0.05, t-test between groups (compared with acute 10 mg·kg⁻¹ dose group) after significant anova.