Figure 2.

Dose-dependent changes in the population of LPAM⁺CD4⁺ memory T-cells in the peripheral circulation following intravenous doses of MECA-367 in the mouse. FVB mice were dosed (1 mg·kg⁻¹i.v.) with IgG₂ control mAb (A) or MECA-367 (B) and blood samples pooled 3 days post-dose analysed for LPAM⁺CD4⁺CD45Rb^low by flow cytometry. Data represent example dot plots, plotting the LPAM⁺ populations of CD4⁺CD45Rb cells. FVB mice were dosed with MECA-367 or IgG₂ control mAb (0.1, 0.3, 1 and 3 mg·kg⁻¹) and 7 days after dosing, levels of LPAM⁺CD4⁺ memory T-cells in each animal were determined by flow cytometry. Data (C) are plotted as fold changes compared with the isotype control as means ± SEM (n = 8). LPAM, lymphocyte Peyer's patch adhesion molecule (integrin α₄β₇).