Figure 4.

Changes in the levels of leukocyte populations over time in response to increasing doses of PF-00547659 over the pre-dose baseline in cynomolgus macaques. (A) mean % change in the absolute number of total lymphocytes. Data are plotted as means ± standard error of means (SEM; n = 4); ***P < 0.005 over 0.01 and 0.05 mg·kg⁻¹ groups, P = 0.01 over 0.1 mg·kg⁻¹ group; (B) mean % change in the absolute number of CD3⁺ lymphocytes. Data are plotted as means ± SEM (n = 4); ***P < 0.005 over 0.01 and 0.01 mg·kg⁻¹ groups, P = 0.008 over 0.05 mg·kg⁻¹ group; (C) mean % change in the absolute number of CD4⁺ lymphocytes. Data are plotted as means ± SEM (n = 4); ***P < 0.005 over 0.01 and 0.1 mg·kg⁻¹ groups, P = 0.009 over 0.05 mg·kg⁻¹ group; (D) mean % change in the absolute number of CD8⁺ lymphocytes. Data are plotted as means ± SEM (n = 4); ***P < 0.005 over 0.01 mg·kg⁻¹ group, P < 0.05 for 0.05 and 0.1 mg·kg⁻¹ groups; (E) mean % change in the absolute number of CD20⁺ lymphocytes. Data are plotted as means ± SEM (n = 4); **P < 0.05 over 0.01, 0.05 and 0.1 mg·kg⁻¹ groups; (F) mean % change in the absolute number of CD16⁺ lymphocytes. Data are plotted as means ± SEM (n = 4).