Table 4.
SERT and 5-HT1A receptor occupancy (%) by WAY-211612
| Brain region | Dose (po) | SERT | 5-HT1A |
|---|---|---|---|
| Prefrontal cortex: | 3 mg·kg−1 | 56.6 ± 4.0 | 6.7 ± 4.0 |
| 30 mg·kg−1 | 73.6 ± 16.2 | 44.7 ± 2.4 | |
| Hippocampus: | 3 mg·kg−1 | 52.2 ± 4.4 | 8.3 ± 8.8 |
| 30 mg·kg−1 | 78.5 ± 13.2 | 48.6 ± 16.6 | |
| Dorsal raphe: | 3 mg·kg−1 | 14.8 ± 8.5 | |
| 30 mg·kg−1 | 82.7 ± 13.6 |
Data in the Table show the displacement by WAY-211612 (as %) of paroxetine (SERT) or WAY-101405 (5-HT1A receptors). Values represent mean ± SEM. n = 3 for SERT and n = 2–3 for 5-HT1A receptors.
Note:Dorsal raphe dissection also contained some surrounding midbrain structures and was not purely dorsal raphe.
SERT, 5-HT transporter.