Table 5.
Effects of WAY-211612 (s.c.) on behaviours in the resident-intruder model
| Vehicle | 3.3 mg·kg−1 | 10 mg·kg−1 | 30 mg·kg−1 | |
|---|---|---|---|---|
| Exploration | 24.5 ± 1.9 | 29.9 ± 2.9 | 31.7 ± 2.6 | 30.8 ± 1.7 |
| Maintenance | 1.4 ± 0.5 | 1.5 ± 0.2 | 1.7 ± 0.5 | 1.7 ± 0.3 |
| Investigation | 49.7 ± 2.3 | 45.5 ± 2.9 | 42.8 ± 3.1 | 43.5 ± 1.6 |
| Sexual | 0.9 ± 0.5 | 0.5 ± 0.2 | 0.6 ± 0.3 | 0.6 ± 0.2 |
| Aggression | 8.2 ± 1.1 | 4.2 ± 0.8* | 3.3 ± 0.9* | 3.0 ± 0.6* |
| Flight submit | 1.4 ± 0.4 | 1.4 ± 0.3 | 2.1 ± 0.5 | 2.4 ± 0.6 |
| Flight escape | 13.9 ± 0.9 | 16.7 ± 0.9 | 17.8 ± 1.3* | 17.9 ± 1.0* |
| Head/body shake | 0.9 ± 0.4 | 1.6 ± 0.4 | 1.3 ± 0.4 | 4.5 ± 1.8* |
| Total behaviour | 1664 ± 78 | 493 ± 126 | 1532 ± 92 | 1538 ± 43 |
Values indicate mean ± SEM percentage values of total behaviours for each motivational category except head/body shake and total behaviours are mean ± SEM of absolute values.
P < 0.05; significantly different to vehicle treatment.