Figure 2.

Efficacy of acute indomethacin dosing. Four days after rats were treated with CFA (0.2 mL) to induce paw inflammation, they were dosed with vehicle, indomethacin (INDO) or INDO-PC (5 mg indomethacin per kg, i.v.) and were assessed for:(A) pain pressure threshold and B) PGE₂ formation in the inflamed paw. A single dose of both indomethacin or INDO-PC provided a significant increase in (A) analgesic efficacy and (B) COX inhibitory activity. *P < 0.05 versus vehicle. n = 5 per group. CFA, complete Freund's adjuvant; COX, cyclo-oxygenase; PGE₂, prostaglandin E₂.