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Plasma levels of indomethacin. Blood was collected from rats at 30 min after dosing with either indomethacin (INDO) or INDO-PC (5 mg indomethacin per kg, i.v.). Plasma was used in HPLC analysis of indomethacin content. Nearly identical circulating levels of indomethacin were seen in both indomethacin-and INDO-PC-treated animals. *P < 0.05 versus vehicle. n = 5 per group. HPLC, high pressure liquid chromatography.
