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. 2009 Apr 2;157(2):179–194. doi: 10.1111/j.1476-5381.2009.00148.x

Figure 2.

Figure 2

Intracellular penetration of nanoparticulate systems containing siRNA and their subsequent mechanism of action after release in the cytoplasm. The mechanism of action of endogenous miRNA is presented here for comparison purposes. miRNA, microRNA; mRNA, messenger RNA; RISC, RNA-induced silencing complex; siRNA, small interfering RNA.