Figure 1.

Rolipram (Rol) reduces fade and concurrent rolipram + cilostamide (Rol + Cil) abolished fade of the inotropic response to 5-HT on left atria from newborn piglets. (A) Represtative experiment showing the response to 10 µmol·L⁻¹ 5-HT in the absence and presence of rolipram, cilostamide and concurrent rolipram + cilostamide on four strips obtained from the same atrium. After the 20th min of 5-HT administration, (-)-isoprenaline (200 µmol·L⁻¹, ISO) was added. (B) Data of experiments with fade of the response to 1 µmol·L⁻¹ 5-HT. Experiments were carried out on two strips from each atrium. (C) Data of experiments with fade of the response to 10 µmol·L⁻¹ 5-HT. Experiments were carried out on two to four strips from each atrium. n refers to number of strips. The experiments were terminated by raising the Ca²⁺ concentration to 9 mmol·L⁻¹ (Ca²⁺). PDEi, PDE inhibitor.