Figure 7.

Neurogenic-evoked electrical responses. Wild-type and W/W^v detrusor preparations were stimulated with single pulses having durations of 0.1, 0.3 and 0.5 ms, which typically evoked excitatory junction potentials (EJPs). In the absence of drugs, similar responses were elicited in both wild-type and W/W^v tissues. Application of atropine (1 µmol·L⁻¹) caused a small reduction in the amplitude of the EJPs in wild-type preparations but did not inhibit those from W/W^v detrusors (see expanded traces of the responses to a pulse of 0.3 ms). In contrast, PPADS (100 µmol·L⁻¹) abolished the atropine-resistant component of EJPs in all tissues.