Figure 7.

PGE₂-stimulated contraction of rings from human (A) coronary, (B) pulmonary and (C) renal arteries in the absence or presence of BGC20-1531 (1 µmol·L⁻¹). Either vehicle (DMSO 0.1%) or BGC20-1531 were incubated with tissues 30 min prior to PGE₂ stimulation. BGC20-1531 had no effect on the PGE₂-mediated contraction of human coronary, pulmonary or renal arteries. Data are representative of mean ± SEM derived from four independent experiments and are normalized to the maximal contractile response observed to KCl (120 mmol·L⁻¹).