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. 2009 Jan 21;156(2):316–327. doi: 10.1111/j.1476-5381.2009.00027.x

Figure 9.

Figure 9

Effects of BGC20-1531 on PGE2-induced changes in common carotid resistance in anaesthetized dogs. Resistance in the vascular bed served by the common carotid artery was decreased by close intra-arterial injection of PGE2 (0.04 µg·kg−1, 15 min apart), as shown on the left hand axis. Ten minutes after a dose of vehicle or BGC20-1531 (1, 3, 10 and 10 mg·kg−1 i.v.) and immediately before a test dose of PGE2, blood samples were taken for measurement of BGC20-1531 levels in plasma (right hand axis). The effects of PGE2 (decreased carotid resistance) were markedly reduced by 10 mg·kg−1 of BGC20-1531. As the plasma levels of BGC20-1531 fell (values marked Post), the effects of the test doses of PGE2 returned. Carotid resistance is presented as % change from baseline and the plasma level of BGC20-1531 as ng·mL−1; data are mean ± SEM (n = 4).