Figure 2.

(A) Superimposed typical recordings of veratridine-induced persistent sodium current evoked by a depolarizing step from a holding potential of −80 to −10 mV in the absence and presence of F 15845 (10⁻⁵ mol·L⁻¹). (B) Effects of F 15845 (10⁻⁷ mol·L⁻¹–10⁻⁴ mol·L⁻¹) on veratridine-induced persistent sodium current evoked by a depolarizing step from a holding potential of −80 to −10 mV. Total quantity of charge (area under the curve) which represented the persistent sodium current was obtained at the end of 3 min superfusion and was determined with respect to stabilized baseline values. Data are expressed as mean ± SEM.