Figure 6.
Cardio-protective effects of 3-(R)-[3-(2-methoxyphenylthio-2-(S)-methylpropyl]amino-3,4-dihydro-2H-1,5 benzoxathiepine bromhydrate (F 15845) in anaesthetized rabbits subjected to 5 min coronary artery occlusion, as assessed by inhibition of ischaemia-induced ST segment changes in the four-limb electrocardiogram. (A) Inhibition (%) of ST segment elevation following oral F 15845 (0.04–10 mg·kg−1) administered 2 h prior to coronary artery occlusion. (B) Mean maximal changes in mean arterial pressure (MAP, left side) and heart rate (HR, right side) induced by intravenous F 15845 (2.5 mg·kg−1) administered 5 min prior to coronary occlusion. Data are mean ± SEM. *P < 0.05 versus vehicle.