Table 2.
Average startle responses of rats after acute treatment of either saline or different doses of apomorphine or amphetamine
| ND Chol | ND CORT | MD Chol | MD CORT | |
|---|---|---|---|---|
| Apomorphine cohort | ||||
| Saline | 603 ± 81 | 725 ± 103 | 786 ± 88 | 707 ± 111 |
| 0.1 mg·kg−1 | 380 ± 54* | 403 ± 46* | 543 ± 53* | 589 ± 95 |
| 0.3 mg·kg−1 | 586 ± 69 | 566 ± 80 | 597 ± 71* | 687 ± 168 |
| 1.0 mg·kg−1 | 856 ± 129 | 1013 ± 163 | 914 ± 115 | 870 ± 161 |
| Amphetamine cohort | ||||
| Saline | 936 ± 123 | 837 ± 163 | 967 ± 96 | 875 ± 79 |
| 0.5 mg·kg−1 | 818 ± 106 | 756 ± 68 | 827 ± 126 | 932 ± 89 |
| 2.5 mg·kg−1 | 805 ± 125 | 755 ± 67 | 906 ± 122 | 1003 ± 128 |
The rats were subjected to either maternal deprivation (MD) or young-adult corticosterone (CORT) treatment or both. Controls were non-deprived (ND) or received a cholesterol (Chol) control pellet. Data are presented as mean ± standard error of the mean (SEM). The number of animals in the apomorphine cohort was n = 10 in each group. The number of animals in the amphetamine cohort was n = 10 each, except MD Chol where n = 9. Differences between the groups were analysed with anova.
*
P < 0.05 for difference with saline within group.