Table 4.
Density of dopamine D1 and D2 receptors in rats subjected to either maternal deprivation (MD) or young-adult corticosterone (CORT) treatment or both
| ND Chol | ND CORT | MD Chol | MD CORT | |
|---|---|---|---|---|
| D1 receptor | ||||
| Accumbens core | 60.1 ± 5.7 | 59.5 ± 2.5 | 72.3 ± 5.3 | 65.5 ± 2.5 |
| Accumbens shell | 65.1 ± 6.4 | 65.1 ± 2.7 | 80.6 ± 6.3 | 70.7 ± 3.3 |
| Caudate | 67.1 ± 3.8 | 69.4 ± 3.1 | 74.0 ± 3.1 | 73.5 ± 1.5 |
| Cingulate cortex | 13.3 ± 0.6 | 14.0 ± 1.2 | 13.8 ± 0.5 | 14.9 ± 0.7 |
| D2 receptor | ||||
| Accumbens core | 59.0 ± 4.0 | 51.0 ± 2.3 | 57.1 ± 2.0 | 64.0 ± 4.2 |
| Accumbens shell | 57.5 ± 3.7 | 50.7 ± 2.9 | 57.9 ± 1.9 | 64.8 ± 5.3 |
| Caudate | 82.0 ± 4.2 | 69.3 ± 4.1 | 76.1 ± 5.0 | 86.5 ± 5.4 |
| Cingulate cortex | 4.5 ± 1.1 | 4.7 ± 2.6 | 2.9 ± 0.5 | 2.4 ± 0.8 |
Data are mean ± SEM of eight rats per group and expressed as fmol·mg−1 estimated tissue equivalent (ETE). Controls were non-deprived (ND) or received a cholesterol (Chol) control pellet. [3H]SCH23390 (D1 receptor) or [3H]YM091512 (D2 receptor) binding density was assessed by autoradiography.