Table 1.

Group and individual patient pathology data

Group summaries	No underlying cirrhosis							Underlying cirrhosis
Gender distribution	2 female; 5 male							1 female; 7 male
Age, years, mean ± SEM	61.29 ± 3.87 (69.00 ± 9.00 F; 58.20 ± 3.87 M)							58.88 ± 3.67 (46 F; 60.71 ± 3.67 M)
Race Distributiona	3 AA, 4 Ca							1 AA, 7 Ca
Individual patient parameters
Gender distribution	F	F	M	M	M	M	M	F	M	M	M	M	M	M	M
Tumour gradeb	WD	WD	PD	MD	MD	PD	MD	MD	MD	PD	PD	PD	MD	PD	MD
TNM stage	NK	IIIB	IIIB	I	IIIA	II	I	II	II	I	II	IIIA	II	NK	I
Focalityc	NK	SF	MF	SF	MF	MF	NK	MF	MF	SF	MF	MF	SF	SF	SF
Tumour size, cm	NK	≤5	5–10	>10	>10	≤5	≤5	5–10	≤5	5–10	≤5	5–10	≤5	≤5	≤5
Resection status (clean margin)	Yes	Yes	No	Yes	No	Yes	Yes	No	Yes	Yes	Yes	Yes	Yes	Yes	Yes
Vascular invasiond	No	No	NK	No	Yes	NK	No	Yes	No	No	Yes	Yes	No	No	No
Lymph invasion	No	No	NK	No	NK	NK	No	Yes	Yes	No	No	Yes	No	No	No
Serum AFPe	NK	Norm	Incr	Incr	NK	Norm	Incr	Incr	Incr	NK	Incr	Incr	Incr	Norm	Incr
Associated disease risk factorsf	Cryp	Cryp	HBV	Et	HCV, HBV	Cryp	Cryp	Et, HCV	Et, HCV	Et, HCV, HBV	Cryp	DILI	HCh	HCV	HCV, Et
Cytoplasmic AQP 9 NTL	1.1	0.5	1.1	0	0.6	0.2	1.0	1.4	0.9	0.3	0.3	1.4	0.3	0.6	1.0
Membrane AQP 9 NTL	1.9	3.8	3.5	2.8	1.0	3.4	3.7	3.6	3.9	3.4	3.4	2.3	3.8	4.0	1.6
Cytoplasmic AQP 9 HCC	0.1	0.3	0.70	1.4	0.10	0.5	1.0	0.9	0.5	0.3	0.3	1.0	0	0.8	0
Membrane AQP 9 HCC	1.8	0.9	0.60	2.0	1.2	0	0.6	0.8	0.1	1.0	1.0	1.3	0.8	0.7	0.6

^aAA, African-American; Ca, Caucasian

^bTumour grade: WD, well differentiated; MD, moderately differentiated; PD, poorly differentiated

^cFocality: NK, not known; SF, single focus; MF, multiple foci

^dNK, not known

^eIncr, increased; Norm, normal; NK, not known

^fEt, ethanol; HCV, hepatitis C viral infection; HBV, hepatitis B viral infection; Cryp, cryptogenic; DILI, drug-induced liver injury; HCh, haemachromatosis

SEM, standard error of the mean; F, female; M, male; AFP, alpha-fetoprotein; NTL, non-tumour liver; AQP, aquaporin; HCC, hepatocellular carcinoma