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MSU (100 μg/ml) inhibits inositol 1,4,5-triphosphate (IP3)-mediated increase in cytosolic Ca2+. A: uncaging of caged IP3 LX-2 cells loaded with a Ca2+-sensing dye (fluorophore fluo-4/AM) results in a detectable increase in cytosolic Ca2+. B: summation of data from a number of control MSU-treated LX-2 cells shows a very clear inhibition of the increase in cytosolic Ca2+ in response to uncaging IP3 (P < 0.001).
