Fig. 7.
Mice lacking ASC (ASC−/−) and NLRP3 (NLRP3−/−) had significantly less upregulation of TGF-β and collagen transcripts after experimental liver fibrosis. A and B: whole liver mRNA transcripts for TGF-β and collagen are significantly less in ASC−/− and NLRP3−/− mice than wild-type after CCl4-induced liver fibrosis (P < 0.01). C and D: whole liver mRNA transcripts for TGF-β and collagen are significantly less in ASC−/− mice than wild-type after TAA-induced liver fibrosis (P < 0.002 and P < 0.01).