Fig. 1.

Inflammatory damage increases during the chronic inflammatory phase of TNBS-induced colitis. Representative examples of hematoxylin and eosin (H&E) staining from vehicle control-treated rat (A) and TNBS-treated rat (B). Gross damage scores (C) and histopathology damage scores (D) were measured 7 days following intrarectal administration of TNBS. Gross damage and histopathological damage were significantly increased in the colons of TNBS-treated animals compared with vehicle-treated animals. Results were expressed by validated scoring methods (18). Values represent means ± SE of 6 experiments. *P < 0.05 vs. vehicle-treated animals.