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. 2009 Apr 9;296(6):G1230–G1237. doi: 10.1152/ajpgi.90508.2008

Fig. 4.

Fig. 4.

Basal levels of ERK1/2 phosphorylation are increased during chronic intestinal inflammation. A: representative immunoblots of basal ERK1/2 (Thr202/Tyr204) phosphorylation (pERK1/2) in colonic smooth muscle from control and TNBS-treated rats. B: densitometric analysis of basal ERK1/2 (Thr202/Tyr204) phosphorylation in colonic smooth muscle from control and TNBS-treated rats. Basal ERK1/2 phosphorylation is significantly increased in smooth muscle cells isolated from the chronically inflamed colons of rats treated with TNBS compared with control (vehicle)-treated rats. ERK1/2 (Thr202/Tyr204) phosphorylation was measured in colonic smooth muscle cells isolated from rat colon 7 days following rectal administration of TNBS or vehicle. Results are expressed in relative densitometric units in samples containing equal amounts of total protein. Values represent means ± SE of 4 experiments on separate animals. *P < 0.05 vs. control.