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Cross-inhibition between P2X2 receptors and α3β4 nAChRs expressed by HEK-293 cells. A: ATP (1 mM)- and ACh (3 mM)-induced inward currents recorded from a HEK-293 cell stably expressing α3β4 nAChRs and transiently transfected with P2X2 receptors. Currents caused by agonist coapplication exhibited cross-inhibition. B: pooled data from experiments shown in A; n = no. of cells. *Significantly different from predicted sum of currents (P < 0.05).
